Donor-recipient Matching in Heart Transplantation

Personalized Donor-Recipient Matching for Organ Transplantation

Organ transplants can improve the life expectancy and quality of life for the recipient but carries the risk of serious post-operative complications, such as septic shock and organ rejection. The probability of a successful transplant depends in a very subtle fashion on compatibility between the donor and the recipient – but current medical practice is short of domain knowledge regarding the co...

The Impact of Donor-Recipient Sex Matching on Survival After Orthotopic Heart Transplantation

Introduction—Single-institution series have suggested that men receiving orthotopic heart transplantation from female donors have decreased survival. No multi-institutional series has comprehensively addressed the issue of donor and recipient sex matching for both male and female orthotopic heart transplantation recipients. Methods and Results—We used data from the multi-institutional prospecti...

Donor Predictors of Allograft Utilization and Recipient Outcomes after Heart Transplantation Khush et al: Donor Influences in Heart Transplantation

High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation.

The relative importance of various human leukocyte antigen (HLA) loci and the resolution level at which they are matched has not been fully defined for unrelated donor transplantation. To address this question, National Marrow Donor Program data from 3857 transplantations performed from 1988 to 2003 in the United States were analyzed. Patient-donor pairs were fully typed for HLA-A, -B, -C, -DRB...

Function Based Donor/Recipient Matching in ECD Kidney Transplantation Using the Creatinine Clearance Match Ratio (CCMR)

Expanded criteria donor kidneys (ECD) have the potential to greatly increase the number of kidneys available for transplantation; however utilization is limited by poorer outcomes [1-5]. One strategy to improve outcomes and secondarily utilization is improved matching of kidneys based on recipient factors such as surface area [6,7], kidney graft size to recipient weight [8] and kidney weight to...